|
|
Peroral infections of birds and mammals with the neuropathogenic fluke Trichobilharzia regenti
Pech, Václav ; Horák, Petr (advisor) ; Blažová, Kateřina (referee)
Migration within the body of an infected host is one of the most important parts in the life cycle of flukes, including schistosomes. Migration of avian and mammalian visceral schistosomes has been a quite well studied topic (Haas a Haeberlein, 2009), which became more attractive after the discovery of T. regenti, an avian schistosome which is able to migrate through the nervous tissues of infected birds and mammals as well. Migration of T. regenti and T. szidati schistosomula within the definitive (duck) and the accidental (mouse) hosts is the main topic of the diploma thesis. This work continues with the research of K. Blažová (Faculty of Science, Charles University in Prague) who studied migration of T. regenti within the definitive hosts infected perorally with cercariae or hepatopancreases of the infected intermediate snail, Radix lagotis (unpblished). She proved that T. regenti schistosomula are able to use the central nervous system for migration to the nasal mucosa of infected birds. In our work, we focused on the early phase of migration within the perorally infected birds and mice. Invasion of esophagus by T. regenti cercariae in vitro is not conditioned by secretion of glandular products, including cathepsin B2 of T. regenti (TrCB2). Activity of TrCB2 against mucins, the main components...
|
guest ::
